Italiano| Ref. | Description | Package | ||||
| SIPT04L | Prothrombin time (PT) | 10×4 ml | ||||
| Ready to use liquid reagent, stable until expiration date. The kit contains high sensitivity thromboplastin in the presence of recombinant human tissue factor (RTF) for the determination in PT citrated human plasma or Protrombin time, ie the time between the addition of calcium and fibrin formation. Since the RTF, that has been used, does not contain contaminant coagulation factors, the kit is characterized by a high sensitivity to the deficiencies of factors X, VII, V and II, making it suitable for estrogen-binding factor dosing: Protrombin time, in fact, depends on the plasma concentrations of Fibrinogen (Factor I), Protrombin (Factor II), Factors V, VII, and X. Therefore, the test allows to measure the deficit of one of the above factors or a combination thereof, / em> in citrated human plasma.
The reagent has been formulated to be insensitive to therapeutic levels of heparin. In the PT analysis, the addition of the patient’s plasma reagent in the presence of calcium ions triggers the activation of the extrinsic pathway. This operation ends in the conversion of fibrinogen into fibrin with the formation of a clot. It comes largely used in monitoring oral oral anticoagulant therapy that causes prolongation of Protrombin Time to reduce the activity of vitamin K acting on coagulant factors II, VII, IX, X and on Protein C and S. Reaction at 37 ° C. Dispense 100 m of citrated plasma and 200 l of PT reagent.
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| SIPTT304040 | aPTT
synthetic phospholipids |
10x4ml | ||||
| Liquid reagent, ready to use and stable until expiration date. Activated Partial Thromboplastin Time (APTT) is the time required for the formation of the clot when adding the citrated plasma of the sample to the Synthetic Phospholipid PHP as a homogeneous and standardized activator, and calcium chloride with the purpose of optimizing the activation of Factor XII and thus activating the coagulative process. The test allows to monitor the factors of the intrinsic system of the coagulative process: factors VIII, IX, XI and XII and factor of Fletcher. It is also largely used in the monitoring of heparin therapy which results in an extension of the partial thromboplastin time proportionally to the amount of heparin present in the sample. It is not sensitive to platelet function or Factor VII.
Dedicated studies have shown that sensitivity to the concentration decrease of factor VIII, IX, XI, XII of the intrinsic pathway of the Synthetic Phospholipid APTT is higher than that of the Ellagic Acid APTT. Furthermore, the Synthetic Phospholipid APTT reagent is extremely sensitive to the presence of Lupus (LAC) antiphospholipid antibodies. Reaction at 37 ° C. Dispensing 100 m of citrated plasma, 100 m reagent and 100 m calcium chloride (supplied separately). |
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| SI1890040 | Calcium chloride (CaCl2) | 1x10ml | ||||
| Use with the APTT Kit Ellagico Acido and APTT Phospholipidic Synthetics. Concentration 0.025 M.
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| SI74102 | Fibrinogen | 10×2 ml | ||||
| Liquid ready reagent. Stable up to the expiration date. The Kit measures the coagulation time, which is the exclusive expression of the amount of fibrinogen present in the sample, using the method originally described by Clauss. In the presence of high concentrations of thrombin, the time required for the formation of the coagulant in diluted plasma is inversely proportional to the concentration of Fibrinogen. Plasma plasma dilution with imidazole buffer (supplied separately) serves to minimize the interference of any anticoagulants such as heparin.
Reaction at 37 ° C. Dispense 200 citrated plasma and 100 m l of PT reagent.
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| SI7500 | Imidazole Buffer | 135 ml | ||||
| To be used with the FIBRINOGEN kit for pre-sampling. Ready-to-use liquid reagent. Stable up to the expiration date. | ||||||
